科学家综述间充质细胞在炎症、免疫疾病和癌症

本期文章：《自然—免疫学》：Online/在线发表

希腊“亚历山大·弗莱明”生物医学科学研究中心George Kollias、Vasiliki Koliaraki综述了间充质细胞在炎症、免疫和癌症的功能。2020年8月3日，《自然-免疫学》发表了该综述。

间充质细胞是中胚层衍生的基质细胞，其主要功能是为器官提供结构支撑、合成和重塑细胞外基质（ECM）以及调节组织发育、体内平衡和修复。近年来对成纤维间充质细胞生物学的详细机制研究表明，它们也参与了免疫调节、干细胞维持和血管功能。现已清楚的是，这些功能一旦出现缺陷，便会促进复杂疾病的发展，例如各种免疫病理学、慢性炎性疾病、组织纤维化和癌症。

在本综述中，研究人员简要概述了成纤维间充质细胞在生理和疾理中的基本作用，并重点介绍了最新的研究，这些研究表明其在单细胞水平上的异质性、组织特异性及其时空功能多样性。

附：英文原文

Title: The mesenchymal context in inflammation, immunity and cancer

Author: Vasiliki Koliaraki, Alejandro Prados, Marietta Armaka, George Kollias

Issue&Volume: 2020-08-03

Abstract: Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and regulating development, homeostasis and repair of tissues. Recent detailed mechanistic insights into the biology of fibroblastic mesenchymal cells have revealed they are also significantly involved in immune regulation, stem cell maintenance and blood vessel function. It is now becoming evident that these functions, when defective, drive the development of complex diseases, such as various immunopathologies, chronic inflammatory disease, tissue fibrosis and cancer. Here, we provide a concise overview of the contextual contribution of fibroblastic mesenchymal cells in physiology and disease and bring into focus emerging evidence for both their heterogeneity at the single-cell level and their tissue-specific, spatiotemporal functional diversity. Koliaraki, Prados, Armaka & Kollias review the roles of fibroblastic mesenchymal cells in tissue homeostasis and immunopathologic diseases, including chronic inflammatory disease, tissue fibrosis and cancer.

DOI: 10.1038/s41590-020-0741-2

Source: https://www.nature.com/articles/s41590-020-0741-2

期刊信息

Nature Immunology：《自然—免疫学》，创刊于2000年。隶属于施普林格·自然出版集团，最新IF：23.53
官方网址：https://www.nature.com/ni/
投稿链接：https://mts-ni.nature.com/cgi-bin/main.plex